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    Since 1998, ENEA (Italian National Agency for New Technology, Energy and the Environment) has been carrying on researches to develop a plant based greenhouse facility for producing plant fresh food at the Italian bases of TNB (Terra Nova Bay) and Dome C (Concordia base) in Antarctica. Accordingly, at the base TNB “Mario Zucchelli” was installed a sustainable closed greenhouse facility PULSA (Plant-based Unit for Life Support in Antarctica). PULSA has been in operation during four campaigns in Antarctica. 1) A complete automatic hydroponics system for plant cultivation in artificial environmental (C.H.G.S., Closed Hydroponic Greenhouse System); 2. A closed module PULSA Unit. A prototype greenhouse module has been conceived and designed as a transportable unit made of a standard container, dimensions of 6055 (l)*2435(w)*2585(h) mm. The installed microclimate conditioning unit included an air heater of about 6.0 kW which can also act as inside air cooling as well as dehumidifier for removing the internal humidity (up to 2.5 kg/h of water) by forcing the air into a drying service. An air ventilation device composed of two fans each of 400 W and air capacity exchanging of 1200 m3/h was also installed to keep necessary air exchange and CO2 concentration. 3) A treating and recycling wastes unit for the purification of water and for the recycling of residual biomass wastes from the hydroponic cycles, 4) A complete automated and remote-controlling system for the germination and the production of the plantlets (Box-Nursery); 5) A simulator for the growth and the yield production of lettuce (SLS) in function of the temperature and the light applied to the crops. Other prototypes still under developing are: a) the multilevel hydroponics design; b) the solar photovoltaic system of 1.1 kWp, to optimize the yield and the autonomy of the enclosed growing volume using artificial and/or Light Emitting Diodes (LEDs) as light sources for plant crop growth. Considerations and comments are reported on the on-going challenge to use PULSA as scientific platform for implementing activities of research and demonstration on plant growth technologies for Space.